In a saucepan over medium heat, melt the unsalted butter, stirring continuously to prevent burning.
Once the butter is melted, add the hot sauce, garlic powder, onion powder, paprika, and white vinegar to the saucepan.
Whisk the mixture together until it is well combined.
Continue to heat the mixture for 5 minutes, stirring occasionally.
Taste the sauce and add salt if desired, adjusting the seasoning to your preference.
Remove the saucepan from heat and allow the buffalo sauce to cool slightly.
Transfer the buffalo sauce to a storage jar or container, and it can be used immediately or stored in the refrigerator for up to 2 weeks.