Preheat your oven to 375°F (190°C) and grease the muffin tin or mini loaf pan with cooking spray or oil.
In a mixing bowl, combine the ground beef, bread crumbs, grated Parmesan cheese, shredded cheddar cheese, chopped onion, minced garlic, egg, Worcestershire sauce, Italian seasoning, salt, and pepper. Mix until all ingredients are well combined.
Scoop the meat mixture into the prepared muffin tin, filling each cavity about halfway. Press a small amount of shredded cheddar cheese into the center of each meatloaf bite, then top with more meat mixture to cover the cheese completely.
Bake in the preheated oven for 25 minutes, or until the meatloaf bites are cooked through and browned on top.
Remove from the oven and let cool for a few minutes before carefully removing the meatloaf bites from the pan.
Consider topping the meatloaf bites with a drizzle of barbecue sauce for added flavor before serving.
Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat in the microwave or oven before serving.