Preheat your oven to 350°F (175°C).
In a mixing bowl, combine the cream of chicken soup, garlic powder, onion powder, salt, and pepper. Mix well to combine.
Place the chicken breasts in the baking dish. If using rice, spread the cooked rice evenly in the dish first, then lay the chicken on top.
Pour the cream of chicken mixture over the chicken. Ensure the chicken is fully coated.
Sprinkle the frozen mixed vegetables over the top of the chicken.
Sprinkle shredded cheddar cheese evenly over the mixture.
Cover the baking dish with aluminum foil and bake in the preheated oven for 20 minutes.
Remove the foil and bake for an additional 10 minutes, or until the chicken is cooked through and the cheese is bubbly and golden.
Remove from the oven and let it sit for a few minutes before serving.
Garnish with fresh parsley if desired.