Crush the Oreo cookies in a mixing bowl until fine crumbs remain. You can use a food processor or place them in a resealable plastic bag and crush with a rolling pin.
Add the softened cream cheese to the crushed Oreo cookies. Mix with a fork or spatula until well combined. The mixture should be a thick dough-like consistency.
Using your hands, form small balls (about 1 inch in diameter) from the mixture and place them on a cookie sheet lined with parchment paper.
Once all the balls are formed, place the cookie sheet in the refrigerator for about 60 minutes to allow the truffles to firm up.
While the truffles are chilling, melt the white chocolate chips in a microwave-safe bowl. Microwave in 30-second intervals, stirring in between, until smooth.
Dip each chilled truffle into the melted white chocolate, using a fork to lift it out and allowing excess chocolate to drip off. Return the truffle to the parchment-lined cookie sheet.
Before the chocolate sets, sprinkle holiday decorations like sprinkles or crushed candy canes over the truffles for a festive touch.
Repeat the dipping process with the semi-sweet chocolate chips for half of the truffles, if desired.
Allow the chocolate coating to set completely, which can take about 30 minutes at room temperature or a shorter time in the refrigerator.
Once set, serve the truffles on a platter or package them as holiday gifts.