Preheat the oven to 375°F (190°C).
In a mixing bowl, combine the softened cream cheese, crumbled bacon, garlic powder, onion powder, salt, and black pepper. Mix until well combined.
Place the chicken breasts on a cutting board and slice each one horizontally, creating a pocket for the filling. Be careful not to cut all the way through.
Stuff each chicken breast with the cream cheese and bacon mixture, using a spoon to fill them generously.
Secure the openings with toothpicks if needed.
Spray a baking dish with cooking spray and place the stuffed chicken breasts in the dish.
Pour the crushed Doritos over the top of the chicken breasts, ensuring they are well-coated.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and reaches an internal temperature of 165°F (74°C).
Remove from the oven and let rest for a few minutes before serving. If using toothpicks, remove them before serving.