Begin by draining the pickle slices and patting them dry with paper towels to remove excess moisture.
In a mixing bowl, combine the flour, garlic powder, onion powder, paprika, cayenne pepper, and salt. Mix well.
In a separate bowl, whisk the two eggs until well-beaten.
Place the breadcrumbs in a third bowl.
Dip each pickle slice first into the seasoned flour mixture, then into the beaten eggs, and finally coat with the breadcrumbs.
Preheat your air fryer to 400°F (200°C).
Lightly spray the pickles with cooking spray to help them crisp up during cooking.
Place the breaded pickles in the air fryer basket in a single layer, ensuring they do not overlap. You may need to cook in batches.
Air fry the pickles for about 8-10 minutes, flipping them halfway through, until they are golden brown and crispy.
Once cooked, remove them from the air fryer and allow them to cool slightly before serving.
For added flavor, consider serving the fried pickles with ranch dressing or a spicy dipping sauce.