Preheat your oven to 350°F (175°C).
In a large mixing bowl, combine the cream cheese, sour cream, garlic powder, onion powder, smoked paprika, salt, and pepper. Mix until smooth and well combined.
Add the cooked shredded chicken, chopped jalapeños, and half of the cheddar and Monterey Jack cheese to the mixture. Stir until everything is evenly coated.
Spread the mixture into an evenly distributed layer in the greased 9x13 inch baking dish.
Top the casserole with the remaining cheeses and sprinkle the crushed tortilla chips evenly across the top.
Bake in the preheated oven for 30-35 minutes, or until the cheese is bubbly and slightly golden brown.
Remove from the oven and let it cool for a few minutes. Garnish with fresh cilantro if desired before serving.