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Mac and Cheese Meatloaf Casserole

A comforting layered dinner dish featuring juicy barbecue-glazed meatloaf topped with creamy mac and cheese and melted mozzarella cheddar blend. Baked to golden perfection, it’s a one-dish meal that’s rich, cheesy, and soul-warming.
Prep Time 18 minutes
Cook Time 50 minutes
Total Time 1 hour 8 minutes
Servings 6 people
Calories 620 kcal

Equipment

  • 1 Mixing bowl Large

Ingredients
  

Main ingredients

  • 2 pounds Lean ground beef
  • 1 cup Ketchup
  • 1 cup Sweet Baby Ray's Hickory & Brown Sugar barbecue sauce
  • 30 Ritz Crackers crushed
  • 2 ounces Lipton onion soup mix
  • 2 Large eggs
  • 3 cups Macaroni noodles
  • 2 cups Milk
  • 10.5 ounces Condensed cheddar cheese soup
  • 1 teaspoon Salt
  • 1 teaspoon Pepper
  • 1 tablespoon Garlic powder
  • 1 tablespoon Onion powder
  • 4 cups Shredded mozzarella and cheddar cheese blend divided

Instructions
 

Instructions

  • Preheat your oven to 375°F so it’s ready when the casserole needs a bake.
  • In a large bowl, mix ground beef with crushed Ritz crackers, onion soup mix, eggs, and salt. Combine fully without overmixing.
  • Press the meat mixture into a greased 9x13-inch baking dish, flattening evenly.
  • In a small bowl, mix ketchup and barbecue sauce. Spread half the mixture over the meatloaf.
  • Bake the meatloaf for 25–30 minutes until mostly cooked through.
  • Boil macaroni noodles according to package directions. Drain well.
  • In a saucepan, stir milk and condensed cheddar cheese soup over medium heat until smooth and heated through.
  • Season the sauce with salt, pepper, garlic powder, and onion powder. Mix well.
  • Fold cooked macaroni into the cheese sauce until fully coated.
  • Remove baked meatloaf from the oven, drain excess grease if needed.
  • Spread macaroni mixture over the meatloaf, top with remaining barbecue sauce and cheese.
  • Return to oven for another 10 minutes until cheese is bubbly and golden. Rest 5 minutes before serving.

Notes

To make it gluten-free, use GF Ritz-style crackers, GF macaroni, and GF condensed cheddar soup. Leftovers keep well in the fridge for 3–4 days or freeze wrapped in foil. Reheat gently covered to retain moisture.