Preheat your oven to 375°F (190°C). Lightly spray a baking dish with cooking spray or oil.
In a large mixing bowl, combine the mayonnaise, garlic powder, onion powder, salt, and black pepper. Mix well until combined.
Add the chicken breasts to the bowl and coat them evenly with the mayonnaise mixture, ensuring each breast is well covered.
In another bowl, mix together the crushed Ritz crackers, shredded cheddar cheese, and grated Parmesan cheese.
Press the cracker and cheese mixture onto the coated chicken breasts, making sure they are thoroughly covered on both sides.
Place the coated chicken breasts into the prepared baking dish in a single layer.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and the topping is golden brown and crispy.
Once cooked, remove from the oven and let rest for a few minutes. Garnish with fresh parsley if desired before serving.